Patient/caregiver was educated on precautions to be exercised while taking Donepezil as follows:
- Potentiation of acetylcholine action in the body, secondary to donepezil use, can result in narrowing of airways and increased effort of breathing. This side-effect of donepezil intake can lead to complications, especially in individuals with history of asthma and COPD. Discuss with your physician regarding your history of breathing disorders, if any, and your safety with donepezil. Promptly report to your physician regarding any incidents of exacerbation of shortness of breath and difficulty breathing, following donepezil use, so that, a change in plan of care could be considered. Observe compliance with inhalers and bronchodilator medications prescribed, if any.
- Donepezil is partially metabolized in the liver and the unmetabolized portion of the drug along with the metabolites is mainly excreted in the urine and feces. Individuals with liver disease cannot metabolize the drug normally, which allows the drug to stay active in blood circulation for longer time, resulting in toxicity and consequent side-effects. So, donepezil must be used with caution in individuals with compromised liver function, with possible multiple dose adjustments, periodical monitoring for liver functions, and close watch for development of any dangerous side-effects and toxicity symptoms.
