Patient/caregiver was educated on precautions to be exercised while taking metaxalone as follows: Take the medication at the same time, every day, to avoid forgetting the medication. Taking the medication at regularly spaced intervals helps to maintain appropriate blood levels of metaxalone needed to derive the desired beneficial effects and also prevent toxicity with the medication. Observe compliance with intake of medication, as ordered. Do not change the dose or frequency of the medication without [...]

Patient/caregiver was educated on contraindications for using Metaxalone as follows: Metaxalone use, especially along with antidepressants, such as, citalopram, fluoxetine, sertraline, and many others can significantly increase the serotonin levels in the body. Very excessive concentrations of serotonin in the brain can lead to serotonin syndrome. Individuals with serotonin syndrome can present with mania, excitement, hallucinations, agitation, insomnia, pounding heartbeat, very rapid heart rate, overactive reflexes, and diarrhea. Metaxalone use, especially in individuals with seizure [...]

Patient/caregiver was educated on contraindications for using Metaxalone as follows: Metaxalone is extensively metabolized in the liver and the inactive metabolites are mainly excreted in the urine. If liver function is deficient, the metabolism of metaxalone can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, in individuals with history of compromised liver function, metaxalone must be [...]

Patient/caregiver was educated on contraindications for using Metaxalone as follows: Do not take metaxalone, if you ever manifested any allergic responses to intake of metaxalone or any other medications belonging to the group of skeletal muscle relaxants, such as, methocarbamol and tizanidine. In the event of an allergic response with any of these medications, check with your physician regarding your safety with intake of metaxalone. Do not take metaxalone along with alcohol, opioid pain medications, [...]

Patient/caregiver was educated on the side-effects of using Metaxalone as follows:  Central nervous system side-effects Metaxalone use can result in episodes of headache, confusion, dizziness, and light-headedness. This risk with metaxalone can be even high when it is taken along with any other products and medications causing central nervous depression, such as, alcohol, opioid pain medications, antidepressants, antianxiety medications, and sedatives. Watching closely for therapeutic response and gradually changing the dose, to help optimum control [...]