Patient/caregiver was educated on precautions to be exercised while taking metaxall as follows: Metaxall use can result in episodes of headache, confusion, dizziness, and light-headedness, thus contributing to increased risk for falls and accidents. This risk with metaxall can be even high when it is taken in high doses, when the medication is taken with a high-fat meal, or along with any other products and medications causing central nervous system (brain) depression, such as, alcohol, [...]

Patient/caregiver was educated on precautions to be exercised while taking metaxall as follows: Take the medication at the same time, every day, to avoid forgetting the medication. Taking the medication at regularly spaced intervals helps to maintain appropriate blood levels of metaxall needed to derive the desired beneficial effects and also prevent toxicity with the medication. Observe compliance with intake of medication, as ordered. Do not change the dose or frequency of the medication without [...]

Patient/caregiver was educated on contraindications for using Metaxall as follows: Metaxall use, especially along with antidepressants, such as, citalopram, fluoxetine, sertraline, and many others can significantly increase the serotonin levels in the body. Very excessive concentrations of serotonin in the brain can lead to serotonin syndrome. Individuals with serotonin syndrome can present with mania, excitement, hallucinations, agitation, insomnia, pounding heartbeat, very rapid heart rate, overactive reflexes, and diarrhea. Metaxall use, especially in individuals with seizure [...]

Patient/caregiver was educated on contraindications for using Metaxall as follows: Metaxall is extensively metabolized in the liver and the inactive metabolites are mainly excreted in the urine. If liver function is deficient, the metabolism of metaxall can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, in individuals with history of compromised liver function, metaxall must be [...]

Patient/caregiver was educated on contraindications for using Metaxall as follows: Metaxall, especially when taken in high doses, can lead to depression of respiratory center in the brain, exacerbation of SOB, and difficulty breathing. Low oxygen levels in the body with elevated carbon-di-oxide levels can contribute to altered levels of consciousness, sedation, slow & shallow breathing, severely compromised endurance and exercise tolerance, extreme fatigue, and development of seizures. Severe cases might also lead to emergency situations, [...]