Patient/caregiver was instructed upon therapeutic uses of Adrenaline as follows:

Adrenaline acts by interacting with alpha and beta receptors located in different body tissues, in various clinical conditions discussed below. The actions of Adrenaline depend and vary widely based on the dose administered and the receptors activated.

Hypotension

• Alpha-1 receptors are chiefly located in the smooth muscle of the blood vessels.
• Stimulation of these alpha-1 receptors by Adrenaline results in vasoconstriction and increase in blood pressure.
• Stimulation of these receptors by Adrenaline reduces the permeability of blood vessels, decreases the loss of fluid from the volume within the blood vessels, which also contributes towards increasing the blood pressure.
• Thus, Adrenaline can be used in the treatment of individuals with history of hypotension.

Bradycardia

• Beta-1 receptors are mainly located in the heart and stimulation of these receptors by Adrenaline results in increased heart rate and force of contraction of the heart muscle.
• This action of increased heart rate by Adrenaline can be employed in treating individuals with history of bradycardia.
• Also, increased force of contraction of heart muscle by Adrenaline can lead to increased pumping action of the heart and contribute to higher volumes of blood pumped into the circulation.
• Thus, Adrenaline can be used as a cardiac stimulant, to treat individuals with history of hypotension.