Patient/caregiver was educated on contraindications for using Metaxalone as follows: Metaxalone use, especially along with antidepressants, such as, citalopram, fluoxetine, sertraline, and many others can significantly increase the serotonin levels in the body. Very excessive concentrations of serotonin in the brain can lead to serotonin syndrome. Individuals with serotonin syndrome can present with mania, excitement, hallucinations, agitation, insomnia, pounding heartbeat, very rapid heart rate, overactive reflexes, and diarrhea. Metaxalone use, especially in individuals with seizure [...]

Patient/caregiver was educated on contraindications for using Metaxalone as follows: Metaxalone is extensively metabolized in the liver and the inactive metabolites are mainly excreted in the urine. If liver function is deficient, the metabolism of metaxalone can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, in individuals with history of compromised liver function, metaxalone must be [...]

Patient/caregiver was educated on contraindications for using Metaxalone as follows: Do not take metaxalone, if you ever manifested any allergic responses to intake of metaxalone or any other medications belonging to the group of skeletal muscle relaxants, such as, methocarbamol and tizanidine. In the event of an allergic response with any of these medications, check with your physician regarding your safety with intake of metaxalone. Do not take metaxalone along with alcohol, opioid pain medications, [...]

Patient/caregiver was educated on the side-effects of using Metaxalone as follows:  Central nervous system side-effects Metaxalone use can result in episodes of headache, confusion, dizziness, and light-headedness. This risk with metaxalone can be even high when it is taken along with any other products and medications causing central nervous depression, such as, alcohol, opioid pain medications, antidepressants, antianxiety medications, and sedatives. Watching closely for therapeutic response and gradually changing the dose, to help optimum control [...]

Patient/caregiver was educated on the side-effects of using Metaxalone as follows:  General allergic reactions                                  Metaxalone use can result in general allergic reactions, such as, skin rashes, hives, and itching. Some patients can present with symptoms of severe allergic and anaphylactic response with metaxalone, such as, difficulty breathing, swelling of face, lips, throat, and tongue, with consequent difficulty breathing. Seek emergency medical help for such findings, especially with difficulty breathing, for any appropriate measures to be [...]