Patient/caregiver was educated on contraindications for using Valproic Acid as follows: Ammonia is a toxic product produced in the body during normal protein metabolism. Conversion of toxic ammonia to less toxic urea takes place significantly in the liver and to a lesser extent in the kidneys, by action of enzymes of the urea cycle. So, normal function of liver and kidney is very important for this uncompromised detoxification of ammonia to urea. In individuals with [...]

Patient/caregiver was educated on contraindications for using Valproic Acid as follows: Valproic Acid carries significant risk of lowering the platelet count and result in episodes of easy and unexplained bleeding. Valproic Acid must be avoided or used with extreme caution in individuals with history of thrombocytopenia, as Valproic Acid carries the risk of aggravating the symptoms of this blood disorder. Individuals with thrombocytopenia can present with easy bruising and small purple patches on the skin [...]

Patient/caregiver was educated on contraindications for using Valproic Acid as follows: Valproic Acid is mainly metabolized in the liver to some active metabolites. If liver function is grossly deficient, the metabolism of Valproic Acid can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, Valproic Acid is contraindicated in individuals with extreme liver failure and can be [...]

Patient/caregiver was educated on contraindications for using Valproic Acid as follows: Valproic Acid can interact with a lot of other medications, thus influencing metabolism and therapeutic benefits of self. Concomitant administration of drugs like phenytoin and carbamazepine can result in the induction of some liver enzymes, which leads to increased metabolism of Valproic Acid. Increased metabolism of Valproic Acid by these enzymes will quickly reduce the blood levels of Valproic Acid, thus compromising the therapeutic [...]

Patient/caregiver was educated on contraindications for using Valproic Acid as follows: Do not take Valproic Acid with alcohol or opioid pain medications, such as, hydrocodone and codeine, as they can further contribute to the dizziness caused by the medication, thus compromising safety. A number of OTC cough medications, antihistamines, and antianxiety medications, also can cause drowsiness upon intake and must be avoided taking along with Valproic Acid. Also, Valproic Acid use can result in damage [...]