Patient/caregiver was educated on contraindications for using Xanax XR as follows:
- Some medications, such as, phenytoin and carbamazepine, induce the enzyme systems needed for the metabolism of Xanax Concurrent administration of these medications with Xanax XR can shorten the duration of Xanax XR action, secondary to quickening of Xanax XR metabolism, and result in compromised therapeutic benefit. If you are being newly started on Xanax XR, discuss with your physician regarding all other medications you are currently taking and their safety with Xanax XR. Also, if you have been taking Xanax XR for long, discuss with your physician regarding your history of Xanax XR intake, when you are being started on any new medication.
- Xanax XR is extensively metabolized in the liver and the inactive metabolites are excreted in the urine. If liver function is deficient, the metabolism of Xanax XR can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, Xanax XR could be avoided in individuals with hepatic dysfunction and an alternative medication considered or used with caution, with periodical monitoring for liver functions and development of any toxic symptoms.
