Patient/caregiver was educated on contraindications for using triazolam as follows:
- When taken together, Triazolam can interact with a number of other medications and can precipitate serious reactions. Some medications, such as, oral contraceptives, some antibiotics, anti-GERD agents like omeprazole, inhibit the enzymes needed for the metabolism of Triazolam. Concurrent administration of these medications with Triazolam can inhibit the metabolism of triazolam. Thus, triazolam stays in the body for prolonged duration of time in comparison to normal and stand the risk of causing toxicity.
- Avoid taking Triazolam with grapefruit juice, as it can also inhibit the enzymes needed for the metabolism of Triazolam. Concurrent administration of grapefruit juice with triazolam can inhibit the metabolism of triazolam. Thus, triazolam stays in the body for prolonged duration of time in comparison to normal and stand the risk of causing toxicity.
- Triazolam, especially when taken in high doses, can lead to depression of respiratory center in the brain and difficulty breathing. Severe cases might also lead to emergency situations, such as, respiratory arrest and can result in serious debility and death. Triazolam must be used with extra caution in individuals with history of breathing issues, such as, asthma and COPD, to prevent development of any episodes of severe SOB and respiratory arrest.
