Patient/caregiver was educated on the side effects of using Tofranil as follows:

Serotonin syndrome

• Tofranil use, especially along with a few other antidepressants, such as, citalopram, fluoxetine, and sertraline, can significantly increase the serotonin levels in the body and lead to development of serotonin syndrome. Individuals can present with mania, excitement, hallucinations, agitation, insomnia, pounding heartbeat, very rapid heart rate, overactive reflexes, and diarrhea.

Vision changes

• Tofranil can result in pupillary dilation and obstruction to the drainage of fluid (aqueous humor) in the eye.
• This can result in increase in the intraocular pressure, leading to glaucoma. Individuals can present with eye pain, headache, and blurred vision with haloes around light.