Patient/caregiver was instructed upon mechanism of action and therapeutic uses of Valproic Acid as follows:
- Entry of sodium ions into the nerve cells, through the sodium channels, result in neuronal firing. Rapid firing of nerve impulses is considered responsible for seizure activity, and mania.
- Gama-amino butyric acid (GABA) is an inhibitory neurotransmitter in the brain that helps with controlling the rapid firing of nerve impulses, and contributes towards relief from seizures and symptoms of mania.
- Valproic Acid is an anticonvulsant medication that increases the levels of GABA in the brain. Valproic Acid also inhibits the breakdown of GABA, consequently leading to increased concentrations of the same in the brain.
- Valproic Acid is also considered to inhibit the entry of sodium into the cells, by inhibiting the sodium channels.
- By increasing the concentrations of GABA in the brain and inhibiting the sodium ion entry into the cells, Valproic Acid helps with controlling the rapid firing of nerve impulses and reducing the excitation of the nerves.
- Thus, Valproic Acid can help with reducing/preventing seizure activity. Valproic Acid can be used as an anticonvulsant in prevention of grand-mal and partial seizures. By reducing the excitation of nerves, Valproic Acid also helps with controlling the symptoms of mania and anxiety.
