Patient/caregiver was educated on contraindications for using Phenazopyridine as follows:
- Phenazopyridine is metabolized in the liver to two important metabolites, acetaminophen/tylenol and aniline. Allergy/hypersensitivity to Tylenol and aniline in general population is a common occurrence. So, phenazopyridine should be avoided in individuals with history of allergic response to Tylenol or aniline.
- The metabolites of phenazopyridine along with the significant unmetabolized portion of the parent drug are excreted in the urine. Individuals with compromised renal function cannot excrete these compounds normally, which allows them to stay in blood circulation for longer time, resulting in toxicity and consequent side-effects. So, phenazopyridine could be avoided or used with caution in individuals with compromised renal function, with possible multiple dose adjustments, periodical monitoring for renal functions, and close watch for development of any dangerous side-effects and toxicity symptoms with the medication.
- Do not take Phenazopyridine, if you ever manifested any allergic response to intake of Phenazopyridine. Discuss your history of allergic response to this medication with your physician, without fail. Also, observe caution with using phenazopyridine, if you ever manifested any allergic response to intake of acetaminophen, as it is a product of phenazopyridine metabolism.
