Patient/caregiver was educated on contraindications for using Nitrofurantoin as follows:
- Nitrofurantoin is significantly metabolized in the liver and if liver function is deficient, the metabolism of Nitrofurantoin can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. Also, long term Nitrofurantoin intake also can lead to hepatic injury, thus compromising liver function. Hepatic injury and altered liver function can also result in increased bilirubin levels in the body and signs and symptoms of jaundice. Individuals can present with itching, dark urine, yellowing of skin and eyes, nausea and vomiting, poor metabolism, and fatigue. So, Nitrofurantoin could be avoided in individuals with hepatic dysfunction and an alternative antibiotic considered or used with caution, with close monitoring for liver functions and development of any toxic symptoms.
- In the event of any current manifestations of any allergic response with this medication, report it to your physician or other health care personnel immediately, to check regarding your safety with continuing on intake of this medication.
