Patient/caregiver was educated on contraindications for using Keppra as follows:
- In the event of any current manifestations of any allergic response with this medication, report it to your physician or other health care personnel immediately, to check regarding your safety with continuing on intake of this medication.
- Individuals with history of mood and behavior disorders, secondary to keppra intake, can present with deterioration of memory and awareness, feeling low and depressed, anxiety, panic attacks, trouble sleeping, gross appetite changes, impulsiveness, agitation, aggression, and suicidal thoughts. Keppra should be used with extreme caution in such individuals with close watch for deterioration of mood and behavior.
- Keppra is minimally metabolized by various pathways to inactive metabolites. Significant portion of the administered drug is unmetabolized, which along with the inactive metabolites is mainly excreted in urine by the kidneys. Individuals with renal disease cannot excrete keppra and metabolites normally, which allows the medication to stay in blood circulation for longer time, resulting in toxicity and consequent side-effects. So, keppra must be used with caution and dose adjustments in individuals with compromised renal function, with periodical monitoring for renal functions and development of any toxic symptoms.
