Patient/caregiver was educated on precautions to be exercised while taking Divalproex as follows:

• 1. Divalproex is mainly metabolized in the liver and excreted by the kidneys in the urine. If liver and renal functions are grossly deficient, the metabolism and excretion of divalproex can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, divalproex is used with extreme caution in individuals with compromised liver and renal functions, with possible multiple dose adjustments, periodical monitoring for liver and renal functions and close watch for development of any dangerous side-effects and toxicity symptoms.
  2. Observe compliance with periodical labs orders for evaluation of liver function, renal function, and platelet count.
  3. If you miss a dose, try taking it at the earliest notice of noncompliance. If it is time for the next dose, skip the missed dose and take the dose scheduled. Do not take an extra dose to try making up for the missed dose. Notify your doctor and other health care personnel regarding your dose noncompliance.