Patient/caregiver was educated on contraindications for using AZO as follows:
- In the event of any current manifestations of any allergic response with this medication, report it to your physician or other health care personnel immediately, to check regarding your safety with continuing on intake of this medication.
- Use of AZO can result in deficiency of enzyme systems (G6PDH enzyme), needed to maintain the integrity of red blood cells. This can result in poor red blood cell integrity, predisposing the cells to lysis, contributing to development of hemolytic anemia. This breakdown of red blood cells can result in elevated levels of the yellow pigment, bilirubin, in the blood, which can result in signs and symptoms of jaundice. Individuals can present with itching, dark urine, yellowing of skin and eyes, nausea and vomiting, poor metabolism, and fatigue. Phenozapyridine is administered with caution in individuals with history of hemolysis and anemia, with close watch maintained for evolving signs and symptoms of jaundice and anemia.
