Patient/caregiver was educated on role of incretins in regulating blood sugars as follows:
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- Post-meal rise in the blood glucose levels act as stimulus for the release of a natural hormone from the intestines, called Incretin. Incretin in turn stimulates secretion of insulin from the pancreas.
- Insulin helps with shifting the glucose from the blood into the cells of body tissues. This helps with lowering and regulating the blood glucose levels.
- Progressively as the blood sugar decreases, the stimulus for incretin release does not exist. So, secretion of incretin and consequently, secretion of insulin also decreases.
- Continued presence of active incretin in circulation can stimulate further release of insulin from pancreas, thus lowering the blood sugars further. This continued lowering of blood sugars can lead to serious hypoglycemic states. This situation can be avoided by limiting the presence of active incretin in circulation.
- The action of incretins is time-bound. As the blood sugars continue to decrease due to the action of insulin and body metabolism, the active incretins present in circulation are progressively subjected to enzymatic breakdown. Destruction of incretin reduces the stimulus for further insulin secretion from the pancreas, thus preventing the blood sugars from getting too low.