Patient/caregiver was educated on precautions to be exercised while taking primidone as follows:
- Primidone only prevents the seizures from happening by reducing the excitation and rapid firing of the nerves. But, primidone does not fix the actual condition causing the seizures. Continue taking primidone as ordered, even if you experience relief from the symptoms. Abrupt discontinuation on primidone intake can result in recurrence of seizure episodes and life-threatening status epilepticus. Discontinuing the medication should only be on your physician’s recommendation.
- Sudden discontinuation of primidone intake, after prolonged use, can result in onset of severe withdrawal symptoms, such as, sleep disturbances, hallucinations, and anxiety. This can also increase the potential for recurrence of seizures and life threatening status epilepticus. Discontinuation on primidone use must be slow and gradual, using tapering doses.
- Primidone is partially metabolized in the liver to many active metabolites. If liver function is grossly deficient, the metabolism of primidone can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, primidone could be avoided in individuals with hepatic dysfunction and an alternative medication considered or used with caution, with dose adjustments, periodical monitoring for liver functions and close watch for development of any toxicity symptoms with the medication.
