Patient/caregiver was educated on contraindications for using Namenda as follows:
- Namenda is partially metabolized in the liver, mostly to inactive metabolites. If liver function is deficient, the metabolism of namenda could be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, in individuals with history of compromised liver function, namenda must be used with caution and possible dose adjustments, periodical monitoring for liver functions and development of any toxicity symptoms with the medication.
- The inactive metabolites of namenda along with the significant unmetabolized portion of the parent drug are excreted in the urine. Individuals with compromised renal function cannot excrete these compounds normally, which allows them to stay in blood circulation for longer time, resulting in toxicity and consequent side-effects. So, namenda must be used with caution in individuals with compromised renal function, with possible dose adjustments, periodical monitoring for renal functions, and close watch for development of any dangerous side-effects and toxicity symptoms with the medication.
