NSAIDs and Mechanism of Action

Patient was educated on NSAIDs and their mechanism of action as follows: NSAID stands for Nonsteroidal anti-inflammatory drugs. These are medications that counter the inflammation in the tissues, by reducing swelling, pain, and temperature. NSAIDs act by inhibiting the cyclooxygenase enzymes, COX-1 and COX-2. Inhibition of cyclooxygenase enzymes result in reduced production of prostaglandins. Since prostaglandins result in swelling of the injured tissues and amplification of the sensitivity to pain, reduction in the production of [...]

Types of Cyclooxygenase Enzymes

Patient was educated on types of cyclooxygenase enzymes as follows: Cyclooxygenase enzymes are produced in the inflammatory cells of the tissues, secondary to an injury. Injured tissues, through the mediation of these cyclooxygenase enzymes, produce chemical mediators of inflammation called prostaglandins. Prostaglandins result in swelling of the injured tissues and amplification of the sensitivity to pain. There are two main types of cyclooxygenase enzymes (COX enzymes) Cyclooxygenase-1 COX-1 is a type of cyclooxygenase enzyme produced [...]

NSAIDs and Renal Disease

Patient was educated on NSAIDs and renal disease as follows: NSAIDs, by inhibiting the cyclooxygenase enzymes, inhibit the production of prostaglandins in all the tissues. Renal prostaglandins help dilation of blood vessels in the kidneys and thereby, reduce the blood pressure. Inhibition of prostaglandin synthesis in the kidneys by NSAIDs, result in vasoconstriction and elevated blood pressure. Constriction of the blood vessels in the kidney can contribute to reduced blood flow to the renal tissue. [...]

NSAIDs and Gastric Ulcers

Patient was educated on NSAIDs and gastric ulcers as follows: Gastric ulcer typically is a side effect of NSAIDs that block COX-1 COX-1 is a type of cyclooxygenase enzyme produced in various tissues of the body, including stomach and gastrointestinal tract. Production of COX-1 in these tissues result in production of prostaglandins. Apart from amplification of pain sensitivity and inducing inflammatory signs, prostaglandins also perform important function of protection of the lining of stomach and [...]

Precautions to be Exercised While Using Nonselective Beta Blockers for Management of Hypertension-2

Patient was educated on precautions to be exercised while using nonselective Beta blockers for management of hypertension as below: Nonselective Beta blockers are contraindicated in individuals with abnormally slow heart rates, such as, in individuals with damaged natural pacemaker of the heart. Nonselective Beta blockers are contraindicated in individuals with history of asthma, COPD, and with any other issues resulting in episodes of difficulty breathing. Observe compliance with any regular lab work ordered. As these [...]