Patient/caregiver was educated on contraindications for Onglyza use as follows:
- Onglyza should be avoided in individuals with history of serious allergic reactions to prior onglyza use.
- Onglyza helps blood sugar regulation by contributing to overall increase in the secretion of insulin from pancreas. This medication will help lower blood sugars only in people whose pancreas is producing insulin naturally. So, use of onglyza does not help in individuals having type I diabetes, with total failure of pancreas to secrete any insulin at all.
- Onglyza is mainly metabolized in the liver. If liver function is deficient, the metabolism of this medication could suffer. This can lead to increased blood levels of the medication for longer periods of time, resulting in toxicity, serious hypoglycemic episodes, and consequent side effects. Onglyza could be avoided for a safer alternative in individuals with such health history. Individuals with history of compromised liver function must discuss with their physician regarding safety with onglyza use. While using onglyza, periodical labs for evaluation of liver function could be ordered in individuals with compromised liver function.
- Onglyza and metabolites are mainly excreted in the urine. Individuals with renal disease cannot excrete this medication and metabolites normally. Onglyza and metabolites can stay in circulation for longer time, resulting in toxicity, serious hypoglycemic episodes, and consequent side effects. Onglyza could be avoided for a safer alternative in individuals with such health history. Individuals with history of compromised renal function must discuss with their physician regarding safety with onglyza use. While using onglyza, periodical labs for evaluation of renal function could be ordered in individuals with compromised kidney function.
