Patient was educated on Beta-2 agonists and their mechanism of action as follows:
- Beta-2 receptors are located mainly at two sites-Bronchial smooth muscle in the respiratory tract and Smooth muscle of the blood vessels.
- Beta-2 agonists are medications that activate these Beta-2 receptors. They are mainly used with regards to their action on Beta-2 receptors of bronchial smooth muscle.
- Phosphorylation (Addition of phosphate) of myosin (contractile protein in the smooth muscle) is needed for the myosin to contract, which leads to smooth muscle contraction.
- Activation of Beta-2 receptors inhibits phosphorylation of myosin, which inhibits the contraction and promotes relaxation of the bronchial smooth muscle.
- Contraction of the bronchial smooth muscle with narrowing of the airways is the major pathology in individuals with history of asthma and COPD.
- So, by promoting relaxation of bronchial smooth muscle with dilation of the airways, Beta-2 agonists help individuals with asthma and COPD, to prevent episodes of acute shortness of breath and dyspnea.