Patient/caregiver was educated on contraindications for using Metaxalone as follows:
- Metaxalone use can sometimes result in poor red blood cell integrity, predisposing the cells to lysis, contributing to development of hemolytic anemia. Anemic individuals can present with pallor of skin, episodes of confusion, dizziness, exacerbated shortness of breath, and compromised endurance. Also, breakdown of red blood cells with metaxalone intake, can result in elevated levels of the yellow pigment, bilirubin, in the blood, leading to signs and symptoms of jaundice, such as, itching, dark urine, yellowing of skin and eyes, nausea and vomiting, poor metabolism, and fatigue. Metaxalone is contraindicated in individuals with history of hemolytic anemia or used with extreme caution, with close watch maintained for development of symptoms of jaundice and anemia.
- Metaxalone is extensively metabolized in the liver and the inactive metabolites are mainly excreted in the urine. If liver function is deficient, the metabolism of metaxalone can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, in individuals with history of compromised liver function, metaxalone must be used with caution and possible multiple dose adjustments, periodical monitoring for liver functions and development of any toxicity symptoms with the medication.
