Patient/caregiver was educated on contraindications for using Metaxall as follows:
- Metaxall use, especially along with antidepressants, such as, citalopram, fluoxetine, sertraline, and many others can significantly increase the serotonin levels in the body. Very excessive concentrations of serotonin in the brain can lead to serotonin syndrome. Individuals with serotonin syndrome can present with mania, excitement, hallucinations, agitation, insomnia, pounding heartbeat, very rapid heart rate, overactive reflexes, and diarrhea.
- Metaxall use, especially in individuals with seizure history, can occasionally result in deterioration of seizure control and fresh episodes of seizures. Metaxall must either be avoided for an alternative or used with extra caution in individuals with seizure history, to prevent exacerbation of seizure episodes.
- Do not take metaxall, if you ever manifested any allergic responses to intake of metaxall or any other medications belonging to the group of skeletal muscle relaxants, such as, methocarbamol and tizanidine. In the event of an allergic response with any of these medications, check with your physician regarding your safety with intake of metaxall.
- Do not take metaxall along with alcohol, opioid pain medications, such as, hydrocodone and codeine, antipsychotic medications, antidepressant medications, anti-seizure medications, muscle relaxants, antihistamines, OTC cough syrups, and any other medications that carry a risk for depression of the central nervous system resulting in episodes of dizziness, confusion, and coma.
