Patient/caregiver was instructed upon therapeutic uses of Tizanidine as follows:

• Norepinephrine is a neurotransmitter synthesized in human body. Upon release, norepinephrine can improve the conduction of nerve impulses to the skeletal muscles and thus increase the force of skeletal muscle contraction.
• Tizanidine is a medication that works by reducing the release of norepinephrine. Inhibition of norepinephrine release by tizanidine leads to inhibition of conduction of nerve impulses from the spinal cord to the muscles.
• Conduction of nerve impulse to the muscle results in muscle contraction. Inhibition of nerve impulse conduction from the spinal cord to the muscle with tizanidine leads to muscle relaxation.

Tizanidine can be used in clinical conditions for control of pain and relief of muscle spasticity and tightness as follows:

Disc prolapse or rupture

• Individuals with history of intervertebral disc prolapse or rupture can present with increased pressure upon and inflammation of nerves running along the spinal cord. This can result in abnormally increased muscle tone, pain, spasticity, and rigidity.
• Tizanidine intake inhibits conduction of impulses along these inflamed nerves to the muscles, help relieve the spasticity and tightness, relax the muscle, and contribute to relief of pain and stiffness.

  Chronic neuropathy

• Individuals with history of poorly controlled diabetes and trigeminal neuralgia can present with irritated and inflamed nerves in the distal extremities and face, respectively.
• This can contribute to chronic neuropathy in such individuals with tingling, discomfort, and pain in the body parts involved.
• Tizanidine inhibits conduction of impulses along these inflamed nerves and contributes to relaxation of neuropathy symptoms, thus offering comfort.