Patient/caregiver was educated on precautions to be exercised while taking orphenadrine as follows:
- Orphenadrine can induce relaxation of bladder with retention of urine and difficulty emptying the bladder. Orphenadrine use can worsen the symptoms of prostate hypertrophy (BPH), increase urinary retention and difficulty emptying the bladder. Orphenadrine could be avoided for a safer alternative in individuals with history of prostate enlargement and hypertrophy. Increased retention of urine in the bladder with orphenadrine can sharply increase the risk for urinary tract infections. While using orphenadrine, individuals with history of BPH and/or frequent UTIs must keep a close watch on symptoms getting worse and report to the physician appropriately.
- Orphenadrine can induce relaxation of intestinal smooth muscle with slowing of bowels and constipation. Orphenadrine use can worsen the symptoms of duodenal or intestinal obstruction, sharply increasing risk for intestinal back-up and in severe cases, even a rupture of intestines. Discuss with your physician regarding history of intestinal blockage or obstruction, if any. Orphenadrine could be avoided for a safer alternative in individuals with history of slow bowels or intestinal obstruction. While using orphenadrine, report any symptoms of gross slowing of bowels to your physician for recommendation on appropriate relief measures.
- Orphenadrine use can result in difficulty with the flow of fluid in the eye that helps to maintain the eye pressure. This can contribute to increased pressure in the eye. Poor control of eye pressure can lead to retinal damage and blurred vision. Orphenadrine could be avoided for a safer alternative in individuals with history of glaucoma. Individuals with history of glaucoma (elevated eye pressure) must be aware of this side-effect in case of orphenadrine use. Such individuals must promptly report to the physician regarding any headaches, eye pain, and vision disturbances. Individuals taking orphenadrine must observe compliance with periodical vision exam for early detection of any retinal damage and blurring of vision.
