Patient/caregiver was educated on precautions to be exercised while taking norflex as follows:
- Norflex is metabolized inside the body by the liver and is excreted out of the body mainly in urine by the kidneys. If liver function is deficient, metabolism of the drug could be compromised, which can result in higher concentrations of the drug in the body for longer periods of time. If kidney function is deficient, elimination of the drug could be compromised, which also can result in higher concentrations of the drug and metabolites in the body for longer periods of time. Either case can contribute to toxicity and consequent side-effects. So, for individuals with history of compromised hepatic and/or renal function, norflex could either be avoided for a safer alternative or used with caution, with close monitoring for symptoms of toxicity with norflex. While taking norflex, periodical labs could be ordered for evaluation of liver and kidney functions. So, maintain compliance with follow-up physician appointments and lab draws ordered. Be accommodative to the plan of dose changes accordingly to achieve an optimum response and prevent development of any undesired side-effects & toxicity.
- Norflex can induce relaxation of bladder with retention of urine and difficulty emptying the bladder. Norflex use can worsen the symptoms of prostate hypertrophy (BPH), increase urinary retention and difficulty emptying the bladder. Norflex could be avoided for a safer alternative in individuals with history of prostate enlargement and hypertrophy. Increased retention of urine in the bladder with norflex can sharply increase the risk for urinary tract infections. While using norflex, individuals with history of BPH and/or frequent UTIs must keep a close watch on symptoms getting worse and report to the physician appropriately.
- Norflex can induce relaxation of intestinal smooth muscle with slowing of bowels and constipation. Norflex use can worsen the symptoms of duodenal or intestinal obstruction, sharply increasing risk for intestinal back-up and in severe cases, even a rupture of intestines. Discuss with your physician regarding history of intestinal blockage or obstruction, if any. Norflex could be avoided for a safer alternative in individuals with history of slow bowels or intestinal obstruction. While using norflex, report any symptoms of gross slowing of bowels to your physician for recommendation on appropriate relief measures.
