Patient was educated on incretin and insulin secretion as follows:
- In a normal individual, after having a meal, food is broken down and digested in the stomach and intestines.
- Blood sugars rise, when carbohydrates are broken down and sugars are absorbed in the intestines.
- Rise in the blood sugars stimulate release of a natural hormone in the human body, called incretin.
- Incretin brings about the secretion of insulin from the pancreas.
- After a while, sugars in the blood are taken up by the tissues, such as liver and muscle, due to the action of insulin, which leads to gradual fall of blood sugar.
- As the blood sugar decreases, the stimulus for fresh incretin secretion gradually subsides.
- An enzyme called dipeptidyl peptidase breaks down the active incretin already in circulation, thereby, reducing the stimulus for insulin secretion from pancreas.