Patient/caregiver was instructed upon therapeutic uses of imipramine as follows:

Bulimia nervosa

• Binge eating and purging, characteristically seen in bulimia nervosa respond to treatment with imipramine.
• Guilt and anxiety brought on by binge eating contribute to repeated purging activity and continues to establish as a vicious cycle of events, leading to the development of the disorder, bulimia nervosa.
• By regulating the concentrations of neurochemicals in the brain, especially levels of serotonin and noradrenaline, imipramine controls the guilt and anxiety, thus preventing the purging activity.
• This contributes to breaking the cycle of binge and purge, thus offering relief from symptoms of bulimia nervosa.

Panic disorders and phobias

• By improving the concentrations of serotonin and noradrenaline in the brain, imipramine can help with stabilizing the mood and allaying unrealistic fears, thus providing relief from panic states and phobia.

Bed-wetting in children

• Action of the neurochemical acetylcholine on the smooth muscle of bladder results in contraction of bladder, bladder emptying, and urination.
• Imipramine reportedly inhibits the action of acetylcholine on the bladder and thus, inhibits bladder emptying. This action of imipramine helps with preventing/reducing episodes of nocturnal urination and bed-wetting in children.