Patient was educated on contraindications for using NSAIDs as follows:
- NSAIDs must be avoided or used cautiously in individuals with history of exacerbation of SOB with episodes of asthma and growth of nasal polyps.
- NSAIDs must be avoided or used cautiously in individuals with history of hypertension and heart failure. Reduced renal function, secondary to NSAIDs intake, can contribute towards compromise in filtration of blood, leading to reduced formation of urine and fluid back up in the body. Fluid accumulation in the body can result in edema and weight gain. This backed up fluid can increase the fluid volume and workload on the heart that is already in failure, thus further worsening the cardiac function.
- NSAIDs are mainly metabolized by the liver and NSAIDs intake can lead to hepatic injury. Individuals with history of compromised liver function cannot metabolize NSAID and this can lead to increased blood levels of NSAID for longer duration, leading to toxicity. NSAID should be avoided or used with extreme caution in such individuals.
- NSAIDs are is significantly excreted in the bile and urine. Individuals with biliary obstructions and compromised renal functions tend to retain the drug in the circulation longer, thus resulting in toxicity. NSAIDs should be avoided or used with extreme caution in such individuals.
