Patient/caregiver was educated on contraindications for using Imipramine as follows:

  1. Imipramine can interact with a number of other medications and can precipitate serious reactions. If you are being newly started on imipramine, discuss with your physician regarding all other medications you are currently taking and their safety with imipramine. Also, if you have been taking imipramine for long, discuss with your physician regarding your history of imipramine intake, when you are being started on any new medication.
  2. Do not take imipramine with alcohol or opioid pain medications, such as, hydrocodone and codeine, as these products can add to the dizziness and confusion caused by imipramine, and contribute to falls and accidents. A number of OTC cough medications and antihistamines, muscle relaxant medications, and antianxiety medications, can potentiate the confusion caused by imipramine and so, must be avoided taking along with imipramine.
  3. Imipramine carries significant risk for obstruction to the flow of aqueous humor, increasing the intraocular pressure, eye pain, headache, blurred vision with haloes around light, and compromised vision. So, imipramine use is contraindicated in individuals with history of glaucoma, especially the closed-angle glaucoma.