Patient was educated on contraindications for using Celebrex as follows:
- Celebrex must be avoided or used cautiously in individuals with history of hypertension and heart failure. Reduced renal function, secondary to Celebrex intake, can contribute towards compromise in filtration of blood, leading to reduced formation of urine and fluid back up in the body. Fluid accumulation in the body can result in edema and weight gain. This backed up fluid can increase the fluid volume and workload on the heart that is already in failure, thus further worsening the cardiac function.
- Celebrex has the potential to compromise coronary circulation and result in chest pain and myocardial infarction. So, Celebrex must be avoided or used cautiously in individuals with history of myocardial infarction. Celebrex must also be avoided during immediate post-surgical period, in individuals who underwent coronary artery bypass grafting (CABG).
- Celebrex is mainly metabolized by the liver and Celebrex intake can lead to hepatic injury. Individuals with history of compromised liver function cannot metabolize Celebrex and this can lead to increased blood levels of Celebrex for longer duration, leading to toxicity. Celebrex should be avoided or used with extreme caution in such individuals.
