Patient was educated on contraindications for ACE inhibitor use as follows:
- Liver disease
- ACE inhibitors are prodrugs, which when taken are activated in the liver. If liver function is deficient, this activation of ACE inhibitor can suffer and so, does their function too.
- Renal disease
- ACE inhibitors are mainly metabolized in the kidneys. Individuals with renal disease cannot metabolize the ACE inhibitors normally. So, these drugs can be toxic in individuals with renal disease.
- Pregnant women
- ACE inhibitors can cross the placental barrier and cause permanent damage to the fetus. So, use of ACE inhibitors should be prohibited in pregnant women.
