Patient/caregiver was educated on contraindications for using Ativan as follows:
- Some medications, such as, phenytoin and carbamazepine, induce the enzymes needed for the metabolism of Ativan. Concurrent administration of these medications with Ativan can quicken the metabolism of ativan and clear the medication out of the body quicker. Thus, ativan stays in the body for shorter duration of time in comparison to normal and results in compromised therapeutic benefit. If you are being newly started on Ativan, discuss with your physician regarding all other medications you are currently taking and their safety with Ativan. Also, if you have been taking Ativan for long, discuss with your physician regarding your history of Ativan intake, when you are being started on any new medication.
- Ativan is extensively metabolized in the liver and the metabolites are excreted in the urine. If liver function is deficient, the metabolism of Ativan can be compromised. In individuals with history of compromised renal function, the excretion of ativan metabolites can be compromised. In either case, ativan and metabolites stay in the body for prolonged duration of time in comparison to normal leading to increased blood levels of the medication and metabolites for longer periods of time. This can lead to increased risk for side-effects and consequent toxicity. So, Ativan could be cautiously administered or avoided for an alternative medication, in individuals with hepatic and/or renal dysfunction. Periodical labs for liver and/or renal function could be ordered and individuals monitored for development of any toxic symptoms. Discuss with your physician regarding history of compromised liver or kidney function, if any.
