Patient/caregiver was educated on contraindications for using Imipramine as follows:
- Imipramine can interact with many antibacterial and antifungal antibiotics, antiarrhythmic medications, antidepressants, and antipsychotic medications, resulting in development or aggravation of underlying cardiac arrhythmias, leading to debility and sudden cardiac death. Avoid taking imipramine along with medications belonging to the above-mentioned groups, to prevent any dangerous arrhythmias from developing.
- Imipramine is mainly metabolized in the liver. If liver function is deficient, the metabolism of imipramine can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in toxicity and consequent side-effects. So, imipramine must be used with caution in individuals with hepatic dysfunction.
- Imipramine is mainly excreted by the kidneys. Individuals with renal disease cannot excrete imipramine metabolites normally. The medication and metabolites of the medication can stay in blood circulation for longer time, resulting in toxicity and consequent side-effects. So, imipramine must be used with caution in individuals with compromised renal function.
