Patient was educated on the side effects of using Nucynta as follows:

  1. Respiratory depression
  • Nucynta affects the respiratory center in the brain through action on the opioid receptors in the brain.
  • This induces slowing down of respirations and the breathing pattern can become irregular.
  • This can result in reduced gas exchange with elevated carbon dioxide and reduced oxygen levels in the body.
  • Overdose of Nucynta can also cause respiratory arrest.
  1. Feeling of high and addiction
  • Nucynta, in the process of altering the perception of pain in the brain, promotes more dopamine in the brain.
  • Increased dopamine in the brain produces a feeling of high, by interacting with the brain’s reward circuit.
  • This feeling of high, experienced by the individuals on Nucynta use, becomes highly desirable and thus adds the potential for addiction to Nucynta.
  • This makes Nucynta one of the most commonly abused drugs.
  1. Tolerance and addiction
  • Individual taking Nucynta at a recommended dose for prolonged time develop tolerance to the drug and experience blunting of the therapeutic response to Nucynta at that dose.
  • Diminishing therapeutic response prompts an individual to increase the dose of medication intake, to derive the desired effect. This sets the cycle for addiction and abuse.
  1. Skin rash
  • Nucynta intake can result in mild skin rash and dermatitis.