Patient/caregiver was educated on contraindications for using doral as follows:
- Doral is extensively metabolized in the liver and the metabolites are excreted in the urine. If liver function is deficient, the metabolism of Doral can be compromised. In individuals with history of compromised renal function, the excretion of doral can be compromised. In either case, doral and metabolites stay in the body for prolonged duration of time in comparison to normal leading to increased blood levels of the medication and metabolites for longer periods of time. This can lead to increased risk for side-effects and consequent toxicity. So, Doral could be cautiously administered or avoided for an alternative medication, in individuals with hepatic and/or renal dysfunction. Periodical labs for liver and/or renal function could be ordered and individuals monitored for development of any toxic symptoms. Discuss with your physician regarding history of compromised liver or kidney function, if any.
- Doral intake can be habit-forming and carries an abuse potential. The risk for addiction and abuse can be even higher, especially in individuals with history of substance abuse. Doral must be used with extreme caution or avoided in such individuals, to prevent any abuse and toxic side-effects with Doral use.
