Patient/caregiver was educated on contraindications for using flurazepam as follows:
- Flurazepam use in expectant mothers could harm the unborn baby and result in pregnancy complications and birth defects. So, Flurazepam use should best be avoided during pregnancy and in women planning to get pregnant. The possibility of a woman being pregnant should be explored before initiating therapy with flurazepam.
- Flurazepam is extensively metabolized in the liver and the metabolites are excreted in the urine. If liver function is deficient, the metabolism of Flurazepam can be compromised. In individuals with history of compromised renal function, the excretion of flurazepam can be compromised. In either case, flurazepam and metabolites stay in the body for prolonged duration of time in comparison to normal leading to increased blood levels of the medication and metabolites for longer periods of time. This can lead to increased risk for side-effects and consequent toxicity. So, Flurazepam could be cautiously administered or avoided for an alternative medication, in individuals with hepatic and/or renal dysfunction. Periodical labs for liver and/or renal function could be ordered and individuals monitored for development of any toxic symptoms. Discuss with your physician regarding history of compromised liver or kidney function, if any.
