Patient/caregiver was educated on contraindications for using Skelaxin as follows:
- Skelaxin is extensively metabolized in the liver and the inactive metabolites are mainly excreted in the urine. If liver function is deficient, the metabolism of skelaxin can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, in individuals with history of compromised liver function, skelaxin must be used with caution and possible multiple dose adjustments, periodical monitoring for liver functions and development of any toxicity symptoms with the medication.
- Skelaxin could interact with a number of other medications and can precipitate serious reactions. If you are being newly started on skelaxin, discuss with your physician regarding all other medications you are currently taking and their safety with skelaxin. Also, if you have been taking skelaxin for long, discuss with your physician regarding your history of skelaxin intake, when you are being started on any new medication.
- Skelaxin use, especially in individuals with history of mood disorders, can occasionally result in exacerbation of mania and depressive symptoms, changes in behavior, hallucinations, and compromised sexual drive. Skelaxin must either be avoided for an alternative or used with extra caution in individuals with such history, to prevent exacerbation of mood disorders.
- Skelaxin use, especially along with antidepressants, such as, citalopram, fluoxetine, sertraline, and many others can significantly increase the serotonin levels in the body. Very excessive concentrations of serotonin in the brain can lead to serotonin syndrome. Individuals with serotonin syndrome can present with mania, excitement, hallucinations, agitation, insomnia, pounding heartbeat, very rapid heart rate, overactive reflexes, and diarrhea.
