Patient/caregiver was educated on contraindications for Saxagliptin use as follows:
- Saxagliptin is mainly metabolized in the liver. If liver function is deficient, the metabolism of this medication could suffer. This can lead to increased blood levels of the medication for longer periods of time, resulting in toxicity, serious hypoglycemic episodes, and consequent side effects. Saxagliptin could be avoided for a safer alternative in individuals with such health history. Individuals with history of compromised liver function must discuss with their physician regarding safety with saxagliptin use. While using saxagliptin, periodical labs for evaluation of liver function could be ordered in individuals with compromised liver function.
- Saxagliptin and metabolites are mainly excreted in the urine. Individuals with renal disease cannot excrete this medication and metabolites normally. Saxagliptin and metabolites can stay in circulation for longer time, resulting in toxicity, serious hypoglycemic episodes, and consequent side effects. Saxagliptin could be avoided for a safer alternative in individuals with such health history. Individuals with history of compromised renal function must discuss with their physician regarding safety with saxagliptin use. While using saxagliptin, periodical labs for evaluation of renal function could be ordered in individuals with compromised kidney function.
- History of acute pancreatitis: A rare, but serious side effect of using saxagliptin is acute pancreatitis, a condition of acute inflammation of pancreas. Individuals with history of pancreatitis could be at increased risk for recurrence of the condition with saxagliptin intake. Such individuals should let their physician know of their health history and discuss their safety with saxagliptin use. Individuals with acute pancreatitis can present with symptoms, such as, severe upper abdominal pain, radiating to the back, along with severe nausea and vomiting. Any new development or worsening of symptoms of pancreatitis while taking saxagliptin must be reported to the physician for appropriate interventions. Saxagliptin could be avoided for a safer alternative in individuals with history of pancreatitis.
