Patient/caregiver was educated on contraindications for using Diazepam as follows:
- Diazepam intake can be habit-forming and carries an abuse potential. The risk for addiction and abuse can be even higher, especially in individuals with history of substance abuse. Diazepam must be used with extreme caution or avoided in such individuals, to prevent any abuse and toxic side-effects with Diazepam use.
- Diazepam use in expectant mothers could harm the unborn baby and result in pregnancy complications, such as, low birth weight baby, small head circumference, and preterm delivery. So, Diazepam use should be avoided during pregnancy and in women planning to get pregnant.
- Diazepam is extensively metabolized in the liver and the metabolites are excreted in the urine. If liver function is deficient, the metabolism of Diazepam can be compromised. In individuals with history of compromised renal function, the excretion of diazepam can be compromised. In either case, diazepam and metabolites stay in the body for prolonged duration of time in comparison to normal leading to increased blood levels of the medication and metabolites for longer periods of time. This can lead to increased risk for side-effects and consequent toxicity. So, Diazepam could be cautiously administered or avoided for an alternative medication, in individuals with hepatic and/or renal dysfunction. Periodical labs for liver and/or renal function could be ordered and individuals monitored for development of any toxic symptoms. Discuss with your physician regarding history of compromised liver or kidney function, if any.
