Patient/caregiver was educated on contraindications for using AZO as follows:
- AZO use tends to increase the blood sugar levels and can compromise the results on labs drawn. Diabetic individuals taking AZO are at increased risk for poor blood sugar control and elevated blood sugar readings. Individuals taking AZO must be aware of symptoms of elevated blood sugars, such as, trouble concentrating, frequent urination, headaches, weakness, and fatigue. Phenozapyridine is administered with caution in individuals with history of poorly controlled blood sugars, with close watch maintained for evolving signs and symptoms of hyperglycemia.
- AZO is partially metabolized in the liver to some active metabolites. If liver function is deficient, the metabolism of AZO could be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. Also, acetaminophen, one of the active metabolites of AZO, carries significant risk for liver injury. So, in individuals with history of compromised liver function, AZO must be used with caution and possible dose adjustments, periodical monitoring for liver functions and development of any toxicity symptoms with the medication.
