Patient/caregiver was educated on contraindications for using Pyridium as follows:
- Pyridium is metabolized in the liver to two important metabolites, acetaminophen/tylenol and aniline. Allergy/hypersensitivity to Tylenol and aniline in general population is a common occurrence. So, Pyridium should be avoided in individuals with history of allergic response to Tylenol or aniline.
- The metabolites of Pyridium along with the significant unmetabolized portion of the parent drug are excreted in the urine. Individuals with compromised renal function cannot excrete these compounds normally, which allows them to stay in blood circulation for longer time, resulting in toxicity and consequent side-effects. So, Pyridium could be avoided or used with caution in individuals with compromised renal function, with possible multiple dose adjustments, periodical monitoring for renal functions, and close watch for development of any dangerous side-effects and toxicity symptoms with the medication.
- Do not take Pyridium, if you ever manifested any allergic response to intake of Pyridium. Discuss your history of allergic response to this medication with your physician, without fail. Also, observe caution with using Pyridium, if you ever manifested any allergic response to intake of acetaminophen, as it is a product of Pyridium metabolism.
