Patient/caregiver was educated on contraindications for using Phenazopyridine as follows:

• Phenazopyridine use tends to increase the blood sugar levels and can compromise the results on labs drawn. Diabetic individuals taking phenazopyridine are at increased risk for poor blood sugar control and elevated blood sugar readings. Individuals taking phenazopyridine must be aware of symptoms of elevated blood sugars, such as, trouble concentrating, frequent urination, headaches, weakness, and fatigue. Phenozapyridine is administered with caution in individuals with history of poorly controlled blood sugars, with close watch maintained for evolving signs and symptoms of hyperglycemia.
• Phenazopyridine is partially metabolized in the liver to some active metabolites. If liver function is deficient, the metabolism of phenazopyridine could be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. Also, acetaminophen, one of the active metabolites of phenazopyridine, carries significant risk for liver injury. So, in individuals with history of compromised liver function, phenazopyridine must be used with caution and possible dose adjustments, periodical monitoring for liver functions and development of any toxicity symptoms with the medication.