Patient/caregiver was educated on contraindications for using Requip as follows:
- Requip is extensively metabolized in the liver to some active and inactive metabolites. If liver function is deficient, the metabolism of Requip can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, in individuals with history of compromised liver function, Requip must be used with caution and possible dose adjustments, periodical monitoring for liver functions and development of any toxicity symptoms with the medication.
- The metabolites of Requip are excreted in the urine. Individuals with compromised renal function cannot excrete the metabolites of Requip normally, which allows them to stay in blood circulation for longer time, resulting in toxicity and consequent side-effects. So, Requip must be used with caution in individuals with compromised renal function, with possible multiple dose adjustments, periodical monitoring for renal functions, and close watch for development of any dangerous side-effects and toxicity symptoms with the medication.
