Patient/caregiver was educated on contraindications for using Pregabalin as follows:
- Pregabalin hardly undergoes any metabolism in the body and is excreted almost unchanged in urine for the most part. Individuals with compromised renal function cannot excrete the medication normally, which allows the medication to stay in blood circulation for longer time, resulting in toxicity and consequent side-effects. So, Pregabalin must be used with extreme caution in individuals with compromised renal function, starting at a low dose and close watch for development of any dangerous side-effects and toxicity symptoms, possible multiple dose adjustments, and periodical monitoring for renal functions.
- Pregabalin carries the risk of aggravating some underlying cardiac arrhythmias leading to severe debility and death. Pregabalin must be avoided or administered with extreme caution in individuals with history of life-threatening cardiac arrhythmias. Report to your physician regarding any new development or exacerbation of signs and symptoms of arrhythmias, such as, episodes of chest pain, rapid heart rate, palpitations, dizziness, and acute shortness of breath, to facilitate a change in your plan of care.
