Patient/caregiver was educated on contraindications for using Donepezil as follows:
- Donepezil use, can result in severe gastrointestinal upset, increased acid secretion in stomach, worsening of heartburn and burning sensation in the stomach, and can result in the formation of gastric ulcers. Individuals with history of gastric ulcers can be at increased risk to present with these side-effects, thus resulting in exacerbation of the condition. Donepezil must be administered with extreme caution in individuals with history of peptic ulcers, with close watch to prevent exacerbation of unpleasant GI symptoms.
- Donepezil is partially metabolized in the liver to both active and some inactive metabolites. These metabolites along with a small unmetabolized portion of the drug are eliminated by in the urine and feces. If liver function is deficient, the metabolism of donepezil could be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, in individuals with history of compromised liver function, donepezil could be used with caution and possible dose adjustments, periodical monitoring for liver functions and development of any toxicity symptoms with the medication.
