Patient/caregiver was educated on contraindications for using Anastrozole as follows:
- Anastrozole use carries the risk for clot formation, resulting in deep venous thrombosis and pulmonary embolism. Individuals can present with symptoms such as, pain and swelling of extremities – especially swelling of the lower extremities with pain in the calf muscle, episode of sudden cough and shortness of breath, episode of chest pain, and any sudden vision changes. So, anastrozole could be avoided or used with extreme caution in individuals with history of thrombus formation.
- Anastrozole is extensively metabolized in the liver, to inactive metabolites. If liver function is deficient, the metabolism of anastrozole can be compromised. This can lead to increased blood levels of the medication for longer periods of time, resulting in increased risk for side-effects and consequent toxicity. So, anastrozole could be avoided in individuals with hepatic dysfunction and an alternative medication considered or used with caution, with periodical monitoring for liver functions and development of any toxic symptoms.
