Patient/caregiver was educated on contraindications for using gabapentin as follows:
- Gabapentin needs acidic environment in the stomach to be absorbed. Use of an antacid can alter this environment in the stomach, thus hindering the absorption of gabapentin and compromising the therapeutic benefit. Avoid using any antacid concurrently with gabapentin. Observing a 2 – 3 hour window between gabapentin and antacid intake can help avoid this complication.
- Gabapentin use, especially in individuals with history of anxiety and bipolar disorder, carries risk of deterioration of mood disorders and worsening of clinical symptoms of mood disorders. Individuals can present with complaints such as, feeling low, anxiety, panic attacks, trouble sleeping, gross appetite changes, impulsiveness, agitation, aggression, and suicidal thoughts. So, gabapentin must be used with caution in such individuals, with periodical monitoring for symptoms of worsening mood and behavior.
- Gabapentin is poorly metabolized by the body and is mainly excreted by the kidneys. Individuals with renal disease cannot excrete gabapentin normally, which allows the medication to stay in blood circulation for longer time, resulting in toxicity and consequent side-effects. Also, gabapentin carries the risk of contributing to exacerbation of renal failure, in individuals with history of the same. So, gabapentin must be used with caution in individuals with compromised renal function, with periodical monitoring for renal functions and development of any toxic symptoms.
